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. 2020 Jun 8;11:46. doi: 10.1186/s13229-020-00356-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Results of the CCA across all individuals within our sample.a Canonical correlations (subplot) and canonical variates sorted in descending order based on their canonical correlations, and based on the percentage of clinical variance explained; b clinical canonical loadings depicting correlations between each of the five clinical canonical variates (V1-V5) and the five SRS subdomain scores in social awareness (SAW), social cognition (SCG), social communication (SCM), social motivation (SM), and restricted and repetitive behaviors (RRB). Canonical variates are sorted in descending order based on the percentage of explained clinical variance, as indicated in shades of green; c and d scatter plots depicting individual observations based on their scores on the second (c) and first (d) canonical variate, which explained the largest percentage of clinical variance. Data points are colored (ASD: yes vs. no) and shaped (22q11.2DS: yes vs. no) by group membership and sized by the individual’s total SRS score; e and f display canonical loadings of each neuroanatomical feature (i.e., cortical volume (CV), surface area (SA), and cortical thickness (CT)) on the second (e) and first (f) canonical variate