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. 2020 Jun 8;20:149. doi: 10.1186/s12866-020-01835-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Metabolic pathways from phosphoenolpyruvate (PEP) to the different fermentation products in P. thermosuccinogenes. The dashed grey arrow represents the glycolysis, which relies on a PP_i-dependent phosphofructokinase. The green arrows represent the malate shunt for the conversion of PEP to pyruvate. ACDH, acetaldehyde dehydrogenase; ACN, aconitase; ACS, acetyl-CoA synthetase; ADH, alcohol dehydrogenase; AK, acetate kinase; CS, citrate synthase; Flx-Hdr, NADH dehydrogenase/heterodisulfide reductase bifurcation complex; FH, fumarate hydratase; FR, fumarate reductase; ICD, isocitrate dehydrogenase; LDHL, l-lactate dehydrogenase; MDH, malate dehydrogenase; ME, malic enzyme; OOR, 2-oxoglutarate:ferredoxin oxidoreductase; PEPCK, phosphoenolpyruvate carboxykinase; PFL, pyruvate formate lyase; PFOR, pyruvate:ferredoxin oxidoreductase; PPdK, pyruvate, phosphate dikinase; PTA, phosphate acetyltransferase; PYK, pyruvate kinase. The figure is adapted from [4]