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IL-17 activates the NF-κB and Fas/FasL/caspase-8/caspase-3 signaling pathways in podocytes in vitro. Western blot analysis was performed to measure the protein levels of Fas, FasL, active-caspase-8, active-caspase-3, p65 and p-p65 in cultured podocytes following IL-17 and/or helenalin treatment. Data are presented as the mean ± standard deviation from three independent repetitions per experiment. *P<0.05, **P<0.01 and ***P<0.001 vs. IL-17. FasL, Fas ligand; p-, phosphorylated.
