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. 2020 Apr 29;20(1):409–417. doi: 10.3892/etm.2020.8698

Figure 5.

Figure 5

NF-κB inhibition by helenalin attenuates IL-17-induced podocyte apoptosis and secretion of IL-1β or TNF-α by podocytes. IL-17 induced the secretion of (A) IL-1β and (B) TNF-α in vitro in a time- and dose-dependent manner. ***P<0.001 vs. 0 ng/ml. (C) NF-κB inhibitor helenalin attenuated IL-17-induced podocyte apoptosis. Helenalin attenuated IL-17-induced the secretion of (D) IL-1β and (E) TNF-α. Data are presented as the mean ± standard deviation from three independent repetitions per experiment. IL, interleukin; TNF-α, tumor necrosis factor-α.