Table 3.

Risk of incident dementia in relation to 5 units higher body mass index measured at different age categories in the Health and Retirement Study

Age category	50–64	65–79	80+
	N = 15,375	N = 15,297	N = 5467
Main modela	0.97 (0.91–1.04)	0.91 (0.86–0.96)	0.89 (0.83–0.95)
Main model, genotypeda	0.95 (0.86–1.06)	0.91 (0.83–1.01)	0.85 (0.73–1.00)
Adjusted for
PGSBMIb	0.96 (0.86–1.06)	0.91 (0.82–1.00)	0.83 (0.72–0.97)
PGSBMI and PGSADc	0.96 (0.86–1.06)	0.91 (0.83–1.00)	0.83 (0.71–0.97)
By tertiles of PGS for BMId
Lowest tertile	0.94 (0.78–1.13)	0.97 (0.83–1.13)	0.84 (0.64–1.10)
Middle tertile	0.92 (0.77–1.10)	0.87 (0.73–1.03)	0.71 (0.52–0.95)
Highest tertile	0.99 (0.84–1.16)	0.89 (0.76–1.05)	0.96 (0.77–1.19)
p value interaction	0.70	0.49	0.42

Hazard rate ratios (95% confidence intervals) of dementia in relation to 5 units higher body mass index measured at different age categories in the Health and Retirement Study sample. All models are adjusted for age, sex, smoking, and education

PGS polygenic score, BMI body mass index, AD Alzheimer’s disease

^aDementia = BMI + age + sex + smoking + education

^bDementia = BMI + age + sex + smoking + education + PGS_BMI

^cDementia = BMI + age + sex + smoking + education + PGS_BMI + PGS_AD

^dDementia = BMI + age + sex + smoking + education + PGS_BMI + BMI*PGS_BMI