Table 2.

Stratified analysis of pooled HR of breast cancer patients with SII on OS, DFS, RFS, and DMFS

Subgroup analysis	No. of studies	No. of patients	HR (95% CI)	p	Effects model	Heterogeneity
						I2 (%)	p
OS
Total	7	2481	1.79 (1.33–2.42)	< 0.001	Random	77.3	<0.001
Molecular stratification
Mixed	3	1804	1.33 (1.09–1.63)	0.005	Fixed	21.9	0.278
TNBC	2	375	2.82 (2.22–3.59)	< 0.001	Fixed	0	0.612
HER2+	2	302	1.71 (1.23–2.39)	0.002	Fixed	23.9	0.252
Cut-off value of SII
≤ 600	3	462	2.03 (1.57–2.62)	< 0.001	Fixed	47.3	0.150
> 600	4	2019	1.63 (1.04–2.56)	0.033	Random	85.9	< 0.001
Method for cut-off determination
ROC analysis	5	2111	1.65 (1.20–2.26)	0.002	Random	68.7	0.012
Median value	2	370	2.14 (1.11–4.14)	0.024	Random	85.8	0.008
Treatment
Mixed	5	1703	2.15 (1.61–2.86)	<0.001	Random	60.5	0.038
No-surgery	2	778	1.23 (0.98–1.56)	0.080	Fixed	0	0.330
DFS/RFS
Total	7	2126	1.79 (1.31–2.46)	<0.001	Random	66.0	0.007
Molecular stratification
Mixed	2	1288	1.34 (0.89–2.01)	0.160	Random	56.6	0.129
Luminal BC	1	161	6.04 (1.82–19.98)	0.003	–	–	–
TNBC	2	375	2.03 (1.06–3.88)	0.033	Random	81.0	0.022
HER2+	2	302	1.94 (0.83–4.56)	0.128	Random	52.0	0.149
Cut-off value of SII
≤ 600	4	623	1.92 (1.20–3.08)	0.006	Random	57.2	0.072
> 600	3	1503	1.70 (1.01–2.88)	0.047	Random	81.1	0.005
Method for cut-off determination
ROC analysis	5	1756	1.68 (1.14–2.47)	0.008	Random	60.7	0.038
Median value	2	370	2.02 (1.05–3.89)	0.035	Random	81.5	0.020
Treatment
Mixed	5	1703	1.82 (1.36–2.42)	< 0.001	Random	52.5	0.078
No-surgery	2	423	2.31 (0.43–12.43)	0.328	Random	86.1	0.007
DMFS
Total	3	1341	1.64 (1.32–2.03)	< 0.001	Fixed	0	0.590