Table 3.

Final Multiple Linear Regression Model (Model 3)

	b Coefficient	Robust SE	P	[95% Conf. Interval]		Standardized Beta
Constant	−9.07	1.600	<.001	−12.249	−5.890	.
eGFR	0.029	0.013	0.036	0.002	0.055	0.49
Sedentary-time	0.056	0.019	0.004	0.018	0.093	1.41
Interaction	−0.0005	0.0002	0.022	−0.0009	−0.0001	−1.22
Age	0.060	0.015	<.001	0.030	0.089	0.39
Sex	−0.187	0.177	0.294	−0.540	0.165	−0.09
Education	−0.021	0.026	0.416	−0.072	0.030	−0.07
FSRP-10	0.009	0.014	0.510	−0.018	0.036	0.07

95% Conf. Interval = 95% confidence interval; Age = age in years; eGFR = estimated glomerular filtration rate; FRSP-10 = Framingham 10 year stroke risk prediction; Interaction = Sedentary-time multiplied by eGFR; SE = standard error; Sedentary-time = total sedentary time per week in hours; Sex = female. Our final model accounted for 33% of the variance in ln WMH volume, of which 3.4% was due to the interaction of sedentary time and kidney function.