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. 2019 Oct 18;28(23):3940–3953. doi: 10.1093/hmg/ddz230

Figure 9.

Figure 9

Smcr8 deficiency exacerbates gain of toxicity in C9-BAC mice. (A) Representative imaging of coronal sections stained with antibodies against poly (GA) (green). Age-matched 7-month-old mice were used to prepare sections in the area of spinal cords. Scale bars: 5 μm. (B) Quantification of the percentage of cells with poly (GA) puncta out of total cells from 3 WT, 4 C9-BAC and 4 Smcr8+/−;C9-BAC mice. (C) Representative imaging of coronal sections stained with antibodies against poly (GP) (red). Age-matched 7-month-old mice were used to prepare sections in the area of spinal cords. Scale bars: 5 μm. (D) Quantification of the percentage of cells with poly (GP) puncta out of total cells from 4 WT, 4 C9-BAC and 3 Smcr8+/−; C9-BAC mice. Error bars represent SEM of four independent experiments. Statistical analyses were performed with one-way ANOVA with Bonferroni’s post hoc test (*P < 0.05, **P < 0.01 and ***P < 0.001).