Table 3. Genotype frequencies of investigated polymorphisms in asbestos-exposed subjects.
Polymorphism | Genotype | All subjects (N=879) N (%) | No disease (N=149) N (%) | Pleural plaques (N=416) N (%) | Asbestosis (N=160) N (%) | Malignant mesothelioma (N=154) |
CARD8 rs2043211 | AA | 389 (44.5) [4] | 74 (50.0) | 167 (40.3) [2] | 74 (46.5) [1] | 74 (48.1) |
p.Cys10Ter | AT | 382 (43.7) | 57 (38.5) | 190 (45.9) | 68 (42.8) | 67 (43.5) |
TT | 104 (11.9) | 17 (11.5) | 57 (13.8) | 17 (10.7) | 13 (8.4) | |
NLRP3 rs35829419 | CC | 785 (89.7) [4] | 133 (89.9) [1] | 375 (90.4) [1] | 145 (90.6) | 132 (86.8) [2] |
p.Gln705Lys | CA | 88 (10.1) | 15 (10.1) | 39 (9.4) | 14 (8.8) | 20 (13.2) |
AA | 2 (0.2) | 0 | 1 (0.2) | 1 (0.6) | 0 |