Figure 1.
IKAS densities of isolated atrial myocytes from patients with normal sinus rhythm (NSR) and chronic atrial fibrillation (CAF). (A) Representative current traces were obtained in atrial myocytes from patients with NSR and CAF. Test pulses ranged from −130mV to +60 mV for 300 ms with a holding potential of −60 mV. The intracellular free Ca2+ was chelated to 500 nmol/L by adding EGTA in pipette solution. In Figure 1A, the difference represented IKAS, which was calculated by subtracting from control to apamin (100 nmol/L). (B) Current-voltage (I–V) relationships of IKAS obtained from NSR and CAF atrial myocytes. * P<0.05, ** P<0.01 versus NSR.