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. 2020 May 29;26:e924215-1–e924215-12. doi: 10.12659/MSM.924215

Figure 3.

Figure 3

Effect of dronedarone (DR) on IKAS in atrial myocytes from patients with normal sinus rhythm (NSR) and chronic atrial fibrillation (CAF). (A, C) Top: representative currents traces recording at baseline and in the presence of DR or DR with apamin in NSR (A) and CAF (C). Bottom: Current-voltage (I–V) relation curves of DR-sensitive IKAS (n=11) and DR+apamin-sensitive IKAS (n=10). (B, D) Top: representative currents traces recording at baseline and in the presence of apamin or apamin with DR in NSR (B) and CAF (D). Bottom: Current-voltage (I–V) relation curves of apamin-sensitive IKAS (n=8) and apamin+DR-sensitive IKAS (n=10). (E) Current-voltage relation curves of IKAS inhibition by DR in NSR (n=8) and CAF (n=6). * P<0.05, ** P<0.01 versus NSR.