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Dose-dependent inhibition of amiodarone and dronedarone on IKAS in atrial myocytes from chronic atrial fibrillation (CAF) patients. (A) Time course of effects on IKAS in atrial myocytes from CAF patients. Baseline keep for 5 minutes, and then perfusion with amiodarone (AM) or dronedarone (DR) for 15 minutes. (B) Dose-response curves of the inhibitory effect of AM and DR on IKAS at −110 mV in atrial myocytes from CAF patients.
