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. 2020 May 29;26:e924215-1–e924215-12. doi: 10.12659/MSM.924215

Figure 5.

Figure 5

Inhibition of amiodarone (AM) and dronedarone (DR) on IKAS in HEK-293 cells. (A) GFP expression shows successfully transfected by the SK2 gene. (B) Current traces evoked by a ramp protocol from −130 mV to +60 mV in symmetrical K+ solution. Current recording in the absence and presence 100 nM apamin. (C, D) Current traces of various concentrations of amiodarone or dronedarone, respectively. (E) Dose-response curves of the inhibitory effect of AM (n=8) and DR (n=8) on IKAS at −110 mV in HEK-293 cells.