Table 2.

Eradication rates of each therapy group

Analysis	VA-dual	VAC-triple	Difference from VAC-triple (adjusted 95% CI for difference)	P value for difference*	P value for non-inferiority†
ITT	84.5% (142/168)	89.2% (149/167)	4.7% (–11.8% to 2.4%)	0.203	0.073
95% CI	78.2% to 89.6%	83.5% to 93.5%
PP	87.1% (142/163)	90.2% (148/164)	3.1% (–9.9% to 3.7%)	0.372	0.024
95% CI	81.0% to 91.8%	84.6% to 94.3%

*The p values were obtained from two-sided comparisons of difference between the VA-dual group and VAC-triple group.

†The p values were obtained from one-sided test comparisons of non-inferiority between the VA-dual group and VAC-triple group.

ITT, intention-to-treat; PP, per protocol; VAC-triple, vonoprazan, amoxicillin and clarithromycin triple therapy; VA-dual, vonoprazan and amoxicillin dual therapy.