Table 1. Primary transmission of spontaneous 117V prion isolates and IPD A117V patient brain to 117VV Tg30 mice.
| Type of brain inoculum | Code | 117VV Tg30 | |||
|---|---|---|---|---|---|
| Total attack rate1 | Clinically affected | Incubation period (days p.i.)2 | Subclinically infected | ||
| 117VSpont-A | I1503 | 9/9 | 2/9 | 566, 733 | 7/93 |
| 117VSpont-B | I1506 | 6/6 | 2/6 | 616, 616 | 4/64 |
| IPD A117V5 | I514 | 5/5 | 0/5 | >400–528 | 5/5 |
| I1321 | 5/5 | 0/5 | >461–828 | 5/5 | |
| I1322 | 4/4 | 0/4 | >327–612 | 4/4 | |
1Total Attack rate is defined as the total of clinically affected and subclinically infected mice as a proportion of the number of inoculated mice. Subclinical prion infection was assessed by IB and/or IHC examination of brain.
2Incubation periods are reported for clinically affected mice in days p.i. When no clinical transmission of prion disease was observed, the interval between inoculation and death (from culling because of senescence, intercurrent illness, or termination of the experiment) is reported as >x–y days.
3Mice with subclinical infection were culled at 273, 404, 588, 657, 658, 728, and 728 days p.i.
4Mice with subclinical infection were culled at 238, 283, 352, and 525 days p.i.
5Primary transmission of IPD A117V prions from patient brain has been previously published [30].
Abbreviations: IB, immunoblotting; p.i., post-inoculation; IHC, immunohistochemistry; IPD, inherited prion disease