Fig 4. Comparison of TH-302 effectiveness for tumours of different hypoxic levels.
The tumour is allowed to grow for 15 days before TH-302 treatment. TH-302 is given every other day starting on the 15th day and the plasma concentration is assumed to have a half life of 3 hours. The high hypoxic case is from the parameters listed in Table 1 while the low hypoxia case assumes a halved oxygen supply rate (rk). Initial cell number is taken from the time step immediately before treatment and final cell number is taken from the time step immediately following treatment. TH-302 treatment kills only 23% of tumour cells in the low hypoxic case while it kills 57% of cells in the high hypoxic case.