Fig 6. Cases of anti angiogenic therapy effect based on combretastatin strength.

Weak treatment corresponds to an anti angiogenic strength parameter of σ = 20, vessel normalization to σ = 30, and vessel destruction to σ = 70. Normoxic area is where [O₂] > 10mmHg, moderate hypoxic where 5 < [O₂] < 10mmHg, and severe hypoxic where [O₂] < 5mmHg. The hypoxic ranges were chosen from the understood ranges of tumour hypoxia ([7, 25] for example). Combretastatin is given every other day starting on the 15th day in decreasing amounts (of magnitudes 1, 0.75, 0.5, 0.25, and 0.1). Notice that there is an optimal middle strength where the increase in normoxic area is maximized.