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. 2020 May 28;16(5):e1008743. doi: 10.1371/journal.pgen.1008743

Fig 6. Metastasis-specific structural variants do not drive metastasis in pre-clinical breast cancer mouse models.

Fig 6

A. Circos plots representing deFuse2 analysis of RNA-seq data for the 41 matched primary and metastatic PyMT tumors.B. BreakDancer algorithm analysis of 10x WGS data from 20 matched pairs of primary and metastatic lesions from FVB/NJ PyMT x MOLF/EiJ and FVB/NJ PyMT x CAST/EiJ animals. For both plots, the names of the genes associated with predicted structural variations are listed in blue in the outermost track by their corresponding chromosome numbers, which are found in the second track. The inner loops represent breakpoints within repetitive elements at both sites (pink loops), repetitive element at one site (tan loops), or within single copy sequence at both sites (blue loops).