Table 1.

Sample characteristics

			Generation (relative to index case)
Demographics	Complete cohort	Index cases	Same	Younger	Older
No. participants/No. families	297/38	38/38	117/25	106/29	36/15
Age (yr)
Mean	42	49	45	29	61
Range	18–83	22–79	18–69	18–47	40–83
SD	15.2	12.0	11.9	8.5	11.5
Personal history of cancer (%)	25 (n = 75/297)	97 (n = 37/38)^a	17 (n = 20/117)	8 (n = 8/106)	28 (n = 10/36)
Gender (% female)	59	61	60	59	53
Race (% non-Hispanic white)	96	92	99	93	100
Health insured (%)	95	95	96	94	94
Employed (% full or part time)	72	66	74	81	47
CES-D (raw scores)
Mean	10.0	10.7	9.9	10.3	9.1
Range	0–41	0–37	0–41	0–36	0–27
SD	8.2	7.7	8.6	8.5	6.1
% scoring at 16 or higher^b	19 (n = 55/285)	26 (n = 9/35)	17 (n = 19/112)	23 (n = 24/104)	9 (n = 3/34)
Cancer worries (raw scores)
Mean	4.6	6.1	4.5	4.4	3.9
Range	3–12	3–12	3–11	3–11	3–9
SD	1.8	2.6	1.6	1.6	1.4
% scoring 9 or higher^c	4 (n = 12/288)	17 (n = 6/35)	3 (n = 3/113)	2 (n = 2/105)	3 (n = 1/35)
IES scores (raw scores)
Mean	14.6	21.9	15.3	12.1	11.2
Range	0–61	0–61	0–57	0–51	0–44
SD	14.0	15.4	14.6	12.3	12.9
% scoring at 26 or higher^b	20 (58/284)	40 (n = 13/35)	23 (27/116)	13 (13/101)	13 (4/31)
Time (mo)^d
Mean	10.2	NA	6.5	18.3	9.0
Range	0–102	NA	0–43	0–102	1–35
SD	15.6	NA	8.5	21.3	10.3

One index case presented with a MSI high, adenomatous polyp in the presence of a family history meeting Amsterdam criteria.

Scores suggesting symptoms of clinical significance.

Report frequent thoughts (1) about developing cancer; (2) that affects their mood; and (3) that affects their daily living activities.

Time between genetic risk notification and provision of genetic services to at risk relative.

SD, standard deviation; IES, Impact of Events Scale; MSI, microsatellite instability.