Table 1.
Characteristics of 6 Individuals With Congenital Leptin Deficiency Before and After Leptin Treatment
| Patient identifier | A | C | E | F | G | H |
|---|---|---|---|---|---|---|
| Age, years | 18.6 | 3.1 | 13.7 | 8.1 | 2.3 | 7.8 |
| Sex | Female | Male | Male | Female | Female | Male |
| Ethnicity | Pakistani | Pakistani | Arab | Pakistani | Turkish | Turkish |
| Previous leptin treatment | Yesa | No | No | No | No | No |
| Baseline characteristics | ||||||
| Height, m | 1.57 | 1.00 | 1.41 | 1.43 | 0.94 | 1.14 |
| Weight, kg | 128.7 | 38.8 | 103.0 | 76.2 | 37.2 | 43.8 |
| BMI, kg/m2 | 52.2 | 38.8 | 52.2 | 37.4 | 42.1 | 33.7 |
| BMI SDS (if < 18 years) | - | 6.8 | 4.4 | 4.3 | 7.4 | 4.1 |
| Fat mass, kg | 70.5 | 21.9 | 57.8 | 59.7 | 19.9 | 23.6 |
| Lean mass, kg | 53.4 | 17.2 | 39.6 | 43.1 | 17.1 | 18.4 |
| % body fat | 56.7 | 55.4 | 58.7 | 29.1 | 53.7 | 56.1 |
| Daily dose of leptin, mg | 20 | 0.25 | 1.5 | 1.2 | 0.8 | 0.8 |
| Duration of leptin treatment, days | 7 | 28 | 7 | 28 | 10 | 7 |
| After leptin therapy | ||||||
| Weight, kg | 126.0 | 38.4 | 101.2 | 74 | N/A | 44.2 |
| Weight change, % baseline | -2.1 | -1.0 | -1.7 | -2.9 | N/A | 0.9 |
| BMI, kg/m2 | 51.3 | 37.9 | 51.3 | 36.4 | N/A | 34.0 |
| Reference (if previously reported) | Refs [6, 13] | Ref [6] |
aSix-month leptin holiday prior to start of this study.
Abbreviations: BMI, body mass index; N/A, data unavailable; SDS, standard deviation score