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Distinct responses to kisspeptin in children who progressed through puberty and those who did not. Girls (open circles) and boys (filled circles) presenting with delayed or stalled puberty underwent kisspeptin-stimulation testing to assess the change in luteinizing hormone in response to exogenous kisspeptin (∆LHkisspeptin). Participants were then followed until age 18 years to determine whether they progressed through puberty spontaneously.
