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. 2020 Jun 9;31(10):107745. doi: 10.1016/j.celrep.2020.107745

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© 2020 The Author(s)

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Nuclear Antigen Recognized by the pSer¹³⁷-Pfn1 Antibody Associates with Poor Survival Among Chemotherapy-Treated Breast Cancer Patients

(A) Representative images of the nuclear staining of human breast tumors by the pSer¹³⁷-Pfn1 antibody. 20X magnification; scale bars, 100 μm.

(B–D) Univariate Kaplan-Meier analyses showing an inverse correlation between nuclear staining by the pSer¹³⁷-Pfn1 antibody and patient survival in the SPECS series (B), UBC series (C), and the TNBC subset of the UBC series (D). OS, overall survival; RFS, relapse-free survival; BCSS, breast cancer-specific survival; TNBC, triple-negative breast cancer.

(E) Univariate Kaplan-Meier analysis of the BCCancer series showing the associations between nuclear staining by the pSer¹³⁷-Pfn1 antibody and poor survival outcome (BCSS) of the chemotherapy-treated breast cancer patients. Log-rank and Wilcoxon tests were used. p < 0.05 was considered statistically significant. Unadjusted p values for the outcome in the chemotherapy-treated group of BCCancer series are displayed.

See also Figures S1–S3 and Tables S1–S9.