Figure 6. WHO10 is an active mobile genetic element in T. globosa and integrates into loci other than FBA1.
Each panel shows a pair of allelic regions from T. globosa strains CBS2947 and CBS764T. Intact WHO10 genes are shown in green, FBA1 fragments in magenta, and host genes in blue. (A-E) Five strain-specific insertions of WHO10 elements into different host loci. At the BXI1 and E1850 loci of CBS2947 (A,B), the 3’ end of the host gene became duplicated, whereas at the CMC4, RKM5 and MIN6 loci of CBS764 (C-E) the host gene was disrupted by the insertion and no part of it became duplicated. All the integrations contain a fragment of FBA1 immediately downstream of WHO10, and most also contain fragments of other genes. Genes are named after their S. cerevisiae orthologs where possible. E1850 is the T. globosa ortholog of T. delbrueckii TDEL0E01850, a gene with no homolog in baker’s yeast.