Skip to main content
. 2020 May 5;9:e54870. doi: 10.7554/eLife.54870

Figure 4. Association of DunedinPoAm with mortality in the Normative Aging Study (NAS).

The figure plots Kaplan-Meier curves for three groups of NAS participants: those with DunedinPoAm 1 SD or more below the mean (‘slow’ DunedinPoAm, blue line); those with DunedinPoAm within 1 SD of the mean (‘average’ DunedinPoAm, gray line); and those with DunedinPoAm 1 SD or more above the mean (‘fast’ DunedinPoAm, red line). Censoring of participants prior to death is indicated with a vertical gray hash mark. The table below the figure details the number of participants at risk per 3 year interval and, in parentheses, the number who died during the interval. The number censored can be calculated by subtracting the number of deaths in an interval from the difference between the number at risk in that interval and the number at risk in the following interval.

Figure 4.

Figure 4—figure supplement 1. Effect-sizes for association of DunedinPoAm and epigenetic clocks with mortality and morbidity in the Normative Aging Study.

Figure 4—figure supplement 1.

Time-to-event analysis of mortality and chronic disease incidence was conducted using Cox proportional hazard models to estimate hazard ratios (HRs) in N = 771 participants. Repeated-measures analysis of chronic disease prevalence was conducted using Poisson regression to estimate incidence rate ratios (IRRs) within a generalized estimating equations framework to account for the nonindependence of repeated observations of individuals (N = 1488 observations of 771 individuals). All models included covariate adjustment for chronological age. Age acceleration residuals for epigenetic clocks were calculated by regressing epigenetic age on chronological age and predicting residual values. All methylation measures were standardized to M = 0 SD = 1 for analysis. Effect-sizes thus reflect risk associated with a 1-SD increase in the methylation measure.