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. 2020 May 26;9:e54903. doi: 10.7554/eLife.54903

Scheme 2. Schema depicting the postnatal roles of Maf and Mafb.

Scheme 2.

In Pai et al., 2019, we discovered that the adult Maf cDKO mice have drastic reduction of MGE-derived cortical interneurons (CINs) and a preferential loss of parvalbumin (PV) INs. In this paper, we aim to identify potential downstream gene targets of Maf and Mafb that are involved in PV CIN fate specification and differentiation. In this paper, we also provide data that suggest adult Maf cDKO animals have spontaneous epileptic activity in vivo.