Table 1.
Baseline characteristics of kidney donors at the Mayo Clinic and Cleveland Clinic
| Characteristics | Potential kidney donors (n = 3317) | Actual kidney donors (n = 2125) |
|---|---|---|
| Demographics | ||
| Age (years) | 43.9 (11.8) | 43.2 (11.2) |
| Male, n (%) | 1402 (42.3) | 906 (42.6) |
| Race, n (%) | ||
| White or unknown | 3050 (92.0) | 1954 (92.0) |
| Black | 119 (3.6) | 80 (3.8) |
| American Indian/Alaska Native | 33 (1.0) | 15 (0.7) |
| Asian | 39 (1.1) | 26 (1.2) |
| Other | 76 (2.3) | 50 (2.4) |
| Risk factors | ||
| Family history of ESRD, n (%) | 1275 (55.5) | 1193 (56.2) |
| Hypertension, n (%) | 632 (19.1) | 335 (15.8) |
| BMI (kg/m2) | 28.0 (5.1) | 27.7 (4.8) |
| Body surface area (m2) | 1.94 (0.23) | 1.92 (0.22) |
| Uric acid (mg/dL) | 5.3 (1.4) | 5.2 (1.4) |
| Glucose (mg/dL) | 93.8 (11.2) | 92.7 (10.1) |
| Kidney function | ||
| Uncorrected mGFR (mL/min) | 113.4 (25.3) | 114.7 (23.2) |
| Corrected mGFR (mL/min/1.73 m2) | 101.3 (19.0) | 103.0 (17.3) |
| CKD-EPI eGFR (mL/min/1.73 m2) | 91.0 (15.6) | 91.3 (15.1) |
| FAS eGFR (mL/min/1.73 m2) | 89.2 (15.7) | 89.7 (14.8) |
| 24-h urine albumin (mg) | 6.9 (16.6) | 5.6 (9.8) |
| 24-h urine protein (mg) | 48.2 (38.4) | 46.5 (34.8) |
| Kidney CT scan measures | ||
| Kidney volume (mm3), left + right | 294 706 (58 098) | 293 479 (54 439) |
| Cortical volume (mm3), left + right | 208 691 (43 275) | 207 048 (40 196) |
| Medullary volume (mm3), left + right | 82 203 (21 022) | 82 307 (20 412) |
| Renal biopsy measures | ||
| Non-sclerotic glomerular volume (μm3 ×106) | 2.72 (1.06) | |
| Glomerular density (per mm3) | 15.7 (7.5) | |
| Mean profile tubular area (μm2) | 4697 (1521) | |
| Nephron number per kidney (×106) | 0.87 (0.39) | |
| Glomerulosclerosis, n (%) | 3.4 (7.7) | |
| Interstitial fibrosis >1%, n (%) | 214 (14.3) | |
Values presented as mean (SD) unless stated otherwise.