Table 2.

Thresholds and prevalence of high GFR by different definitions across age groups

Commonly used high GFR definitions	Age group (years)
	18–29 (n = 459)	30–39 (n = 790)	40–49 (n = 1046)	50–59 (n = 721)	60–69 (n = 272)	70–75 (n = 29)	P-value*
Corrected mGFR, overall threshold (>134 mL/min/1.73 m2)
>95th percentile (mL/min/1.73 m2)	>134	>134	>134	>134	>134	>134
High GFR (%)	10.7	8.0	3.4	2.8	0.0	0.0	<0.001
CKD-EPI eGFR overall threshold (>118 mL/min/1.73 m2)
>95th percentile (mL/min/1.73 m2)	>118	>118	>118	>118	>118	>118
High GFR (%)	27.2	4.3	0.57	0.14	0.37	0.0	<0.001
Corrected mGFR, age-based threshold (>164 mL/min/1.73 m2 – 0.730 × age)
>95th percentile (mL/min/1.73 m2)	>151–143	>142–136	>135–128	>127–121	>120–114	113–109
High GFR (%)	5.0	5.3	4.7	5.8	3.3	3.4	0.67
CKD-EPI eGFR age-based threshold (>146 mL/min/1.73 m2 – 0.813 × age)
>95th percentile (mL/min/1.73 m2)	>131–122	>121–114	>113–106	>105–98	>97–90	>89–85
High GFR (%)	7.4	4.3	4.0	4.0	8.5	6.9	0.004
Alternative high GFR definitions
FAS eGFR age-based threshold (>149 mL/min/1.73 m2 – 0.843 × age)
>95th percentile (mL/min/1.73 m2)	>134–125	>124–116	>115–108	>107–99	>98–91	>90–86
High GFR (%)	2.2	6.1	7.0	4.2	2.6	0.0	<0.001
Uncorrected mGFR age-based threshold (>198 mL/min/1.73 m2 – 0.943 × age)
>95th percentile (mL/min)	>181–171	>170–161	>160–152	>151–142	>141–133	>132–127
High GFR (%)	4.4	4.9	5.6	6.0	3.3	3.4	0.48
Uncorrected mGFR age-height-gender–based threshold
>95th percentile (mL/min)	–a	–a	–a	–a	–a	–a
High GFR (%)	4.4	5.4	4.9	7.1	2.9	0.0	0.03

^*Chi-square test.

^a95th percentile (mL/min) = 14.297 – 0.881 × age (in years) + 1.173 × height (in cm) + 8.062 (if male).