Table 4.
Characteristics of potential and actual kidney donors stratified by age-based high GFR
| Characteristics | Age-based mGFR (mL/min/1.73 m2) |
Age-based eGFR (mL/min/1.73 m2) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Potential donors (n = 3317) |
Actual donors (n = 2125) |
Potential donors (n = 3317) |
Actual donors (n = 2125) |
|||||||||
| High GFR (n = 166) | Normal GFR (n = 3151) | P-value | High GFR (n = 99) | Normal GFR (n = 2026) | P-value | High GFR (n = 164) | Normal GFR (n = 3153) | P-value | High GFR (n = 95) | Normal GFR (n = 2030) | P-value | |
| Demographic | ||||||||||||
| Mean age (years) | 44 | 44 | 0.98 | 43 | 43 | 0.62 | 44 | 44 | 0.81 | 43 | 43 | 0.70 |
| Male, % | 43 | 42 | 0.89 | 39 | 43 | 0.50 | 33 | 43 | 0.01 | 31 | 43 | 0.01 |
| Race, % | ||||||||||||
| White or unknown | 86 | 92 | 0.005 | 85 | 92 | 0.008 | 70 | 93 | <0.0001 | 62 | 93 | <0.0001 |
| Black | 6.0 | 3.5 | 0.08 | 7.1 | 3.6 | 0.08 | 23 | 2.6 | <0.0001 | 30 | 2.6 | <0.0001 |
| Other | 7.8 | 4.3 | 0.03 | 8.1 | 4.1 | 0.06 | 7.3 | 4.3 | 0.07 | 8.4 | 4.1 | 0.04 |
| Risk factors | ||||||||||||
| Family history of ESRD, % | 58 | 55 | 0.58 | 58 | 56 | 0.77 | 57 | 55 | 0.71 | 57 | 56 | 0.89 |
| Hypertension, % | 20 | 19 | 0.78 | 12 | 16 | 0.31 | 20 | 19 | 0.88 | 13 | 16 | 0.39 |
| Systolic blood pressure (mmHg) | 122 | 122 | 0.52 | 118 | 121 | 0.14 | 123 | 121 | 0.21 | 121 | 120 | 0.77 |
| Diastolic blood pressure (mmHg) | 74 | 74 | 0.47 | 73 | 73 | 0.56 | 74 | 74 | 0.72 | 73 | 73 | 0.80 |
| BMI (kg/m2) | 29 | 28 | 0.02 | 28 | 28 | 0.21 | 28 | 28 | 0.79 | 28 | 28 | 0.88 |
| Body surface area (m2) | 1.95 | 1.94 | 0.39 | 1.95 | 1.93 | 0.26 | 1.89 | 1.94 | 0.003 | 1.87 | 1.93 | 0.009 |
| Uric acid (mg/dL) | 5.0 | 5.3 | 0.006 | 4.9 | 5.2 | 0.008 | 4.9 | 5.3 | <0.0001 | 4.7 | 5.2 | 0.0002 |
| Fasting glucose (mg/dL) | 96 | 94 | 0.01 | 94 | 93 | 0.30 | 93 | 94 | 0.49 | 92 | 93 | 0.29 |
| CT scan measures | ||||||||||||
| Total kidney volume (cm3) left + right | 354 | 291 | <0.0001 | 348 | 291 | <0.0001 | 330 | 293 | <0.0001 | 324 | 292 | <0.0001 |
| Total cortex volume (cm3) left + right | 249 | 207 | <0.0001 | 245 | 205 | <0.0001 | 235 | 207 | <0.0001 | 227 | 206 | 0.0001 |
| Total medulla volume (cm3) left + right | 98 | 81 | <0.0001 | 100 | 81 | <0.0001 | 88 | 82 | <0.0001 | 89 | 82 | 0.01 |
| Kidney function | ||||||||||||
| 24-h urine protein (mg) | 60 | 48 | 0.0005 | 53 | 46 | 0.09 | 51 | 48 | 0.39 | 45 | 47 | 0.68 |
| 24-h urine albumin (mg) | 11 | 6.7 | 0.002 | 6.5 | 5.6 | 0.41 | 9.8 | 6.7 | 0.05 | 3.6 | 5.7 | 0.09 |
| Biopsy measures | ||||||||||||
| Glomerular volume (mm3) | – | – | – | 0.0027 | 0.0027 | 0.97 | – | – | – | 0.0028 | 0.0027 | 0.65 |
| Glomerular density (per mm3) | – | – | – | 18.1 | 15.5 | 0.005 | – | – | – | 15.5 | 15.7 | 0.82 |
| Mean profile tubular area (μm2) | – | – | – | 4599 | 4702 | 0.57 | – | – | – | 4719 | 4696 | 0.91 |
| Nephron number per kidney (×106) | – | – | – | 1.11 | 0.86 | <0.0001 | – | – | – | 0.95 | 0.87 | 0.10 |
| Glomerulosclerosis, % | – | – | – | 3.4 | 3.4 | 0.99 | – | – | – | 3.9 | 3.4 | 0.66 |
| Cortical fibrosis >1%, % | – | – | – | 14.9 | 14.3 | 0.89 | – | – | – | 13.1 | 14.4 | 0.78 |