Table 5.
Characteristics of potential and actual kidney donors stratified by age-based and age-height-gender–based high uncorrected mGFR (mL/min)
| Characteristics | Age-based mGFR (mL/min) |
Age–height–gender-based mGFR (mL/min) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Potential donors (n = 3317) |
Actual donors (n = 2125) |
Potential donors (n = 3317) |
Actual donors (n = 2125) |
|||||||||
| High GFR (n = 166) | Normal GFR (n = 3151) | P-value | High GFR (n = 99) | Normal GFR (n = 2026) | P-value | High GFR (n = 164) | Normal GFR (n = 3153) | P-value | High GFR (n = 95) | Normal GFR (n = 2030) | P-value | |
| Demographics | ||||||||||||
| Mean age (years) | 44 | 44 | 0.89 | 43 | 43 | 0.95 | 44 | 44 | 0.94 | 43 | 43 | 0.90 |
| Male, % | 78 | 40 | <0.0001 | 76 | 41 | <0.0001 | 42 | 42 | 0.99 | 36 | 43 | 0.20 |
| Race, % | ||||||||||||
| White or unknown | 87 | 92 | 0.008 | 87 | 92 | 0.09 | 84 | 92 | 0.0002 | 84 | 92 | 0.002 |
| Black | 5.9 | 3.5 | 0.10 | 5.3 | 3.7 | 0.43 | 6.9 | 3.4 | 0.02 | 7.1 | 3.6 | 0.08 |
| Other | 7.6 | 4.3 | 0.04 | 7.4 | 4.1 | 0.13 | 8.7 | 4.2 | 0.006 | 9.1 | 4.1 | 0.02 |
| Risk factors | ||||||||||||
| Family history of ESRD, % | 59 | 55 | 0.44 | 60 | 56 | 0.44 | 56 | 56 | 0.93 | 57 | 56 | 0.93 |
| Hypertension, % | 33 | 18 | <0.0001 | 16 | 20 | 0.25 | 31 | 18 | <0.0001 | 16 | 19 | 0.34 |
| Systolic blood pressure (mmHg) | 128 | 121 | <0.0001 | 123 | 120 | 0.15 | 127 | 121 | <0.0001 | 122 | 120 | 0.22 |
| Diastolic blood pressure (mmHg) | 77 | 74 | <0.0001 | 75 | 73 | 0.02 | 77 | 74 | <0.0001 | 75 | 73 | 0.02 |
| BMI (kg/m2) | 33 | 28 | <0.0001 | 32 | 28 | <0.0001 | 34 | 28 | <0.0001 | 33 | 28 | <0.0001 |
| Body surface area (m2) | 2.25 | 1.92 | <0.0001 | 2.22 | 1.91 | <0.0001 | 2.10 | 1.93 | <0.0001 | 2.06 | 1.92 | <0.0001 |
| Uric acid (mg/dL) | 5.9 | 5.2 | <0.0001 | 5.7 | 5.2 | 0.0002 | 5.4 | 5.3 | 0.18 | 5.1 | 5.2 | 0.51 |
| Fasting glucose (mg/dL) | 99 | 94 | <0.0001 | 97 | 93 | 0.0002 | 98 | 94 | <0.0001 | 96 | 93 | 0.005 |
| CT scan measures | ||||||||||||
| Total kidney volume (cm3), left + right | 396 | 289 | <0.0001 | 393 | 289 | <0.0001 | 363 | 291 | <0.0001 | 358 | 290 | <0.0001 |
| Total cortex volume (cm3), left + right | 279 | 205 | <0.0001 | 274 | 204 | <0.0001 | 255 | 206 | <0.0001 | 247 | 205 | <0.0001 |
| Total medulla volume (cm3), left + right | 107 | 81 | <0.0001 | 107 | 81 | <0.0001 | 99 | 81 | <0.0001 | 101 | 81 | <0.0001 |
| Kidney function | ||||||||||||
| 24-h urine protein (mg) | 67 | 47 | <0.0001 | 60 | 46 | 0.0007 | 65 | 47 | <0.0001 | 55 | 46 | 0.03 |
| 24-h urine albumin (mg) | 16 | 6.4 | <0.0001 | 9.6 | 5.4 | 0.0004 | 15 | 6.4 | <0.0001 | 7.8 | 5.5 | 0.05 |
| Biopsy measures | ||||||||||||
| Glomerular volume (mm3) | – | – | – | 0.0032 | 0.0027 | 0.0009 | – | – | – | 0.0029 | 0.0027 | 0.14 |
| Glomerular density (per mm3) | – | – | – | 14.0 | 15.7 | 0.07 | – | – | – | 15.8 | 15.7 | 0.92 |
| Mean profile tubular area (μm2) | – | – | – | 5239 | 4673 | 0.004 | – | – | – | 4799 | 4692 | 0.57 |
| Nephron number per kidney (×106) | – | – | – | 1.05 | 0.86 | 0.0002 | – | – | – | 1.06 | 0.86 | <0.0001 |
| Glomerulosclerosis, % | – | – | – | 3.6 | 3.4 | 0.88 | – | – | – | 3.4 | 3.4 | 0.99 |
| Cortical fibrosis >1%, % | – | – | – | 13.9 | 14.4 | 0.91 | – | – | – | 14.1 | 14.4 | 0.95 |