Table 1.
Results of MRE shear stiffness (3D at 90 Hz) and renal blood flow by ASL in normal controls and patients with diabetes grouped by CKD stage based on eGFR
| Participant group (N = 43) | Age, mean ± SD | Sex (M/F), n/n | Race (AA/ non-AA), n/n | eGFR (mL/ min/1.73 m2), mean ± SD | Shear stiffness (Pa; 3D, 90 Hz), mean ±SD |
ASL perfusion (mL/min/100 g tissue), mean ± SD |
||
|---|---|---|---|---|---|---|---|---|
| Right kidney | Left kidney | Right kidney | Left kidney | |||||
| Normal controls (n = 13 | 50 ± 17 | 7/6 | 1/12 | 94 ± 20 | 5784 ± 687 (n = 12) | 5401 ± 673 (n = 12) | 491 ± 158 (n = 12) | 468 ± 117 (n = 12) |
| Diabetes, no nephropathy (n = 2) | 61 ± 4 | 2/0 | 0/2 | 100 ± 9 | 6076 ± 919 | 5709 ± 432 | 584 (n = 1) | 601 (n = 1) |
| CKD Stage 1 (n = 3) | 44 ± 15 | 2/1 | 2/1 | 119 ± 9* | 4674 ± 530* | 5078 ± 680 | 446 ± 180 | 399 ± 130 |
| CKD Stage 2 (n = 5) | 64 ± 9 | 1/4 | 2/3 | 69 ± 4* | 5179 ± 453 | 4778 ± 380 | 405 ± 136 | 379 ± 123 |
| CKD Stage 3 (n = 14) | 65 ± 8 | 10/4 | 2/12 | 45 ± 10*** | 4878 ± 1184* | 4780 ± 877 | 310 ± 110** | 294 ± 80*** |
| CKD Stage 4 (n = 4) | 68 ± 10 | 2/2 | 0/4 | 23 ± 4*** | 5163 ± 686 | 4409 ± 550* | 228 ± 10* (n = 3) | 231 ± 3* (n = 2) |
| CKD Stage 5 (n = 2) | 60 ± 29 | 1/1 | 1/1 | 14 ± 0.1*** | 4126 ± 1365* | 3809 ± 837* | 161 ± 14* | 143 ± 51** |
Significance in comparisons of means with the normal controls: *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001.
AA, African American.