Table 1.

Hamilton Rating Scale for Depression and secondary outcomes by group at 0, 7, 12 and 18 months (see supplementary Table 2 for a more detailed version of this table)

Dependent variable	RO DBT group, adjusted mean	TAU, adjusted mean	Difference	95% CI	P	Evidence ratio (d > 0)a
Hamilton Rating Scale for Depression
Baseline	23.14	23.14	−0.05	−4.44 to 4.34	0.979	1.10
7 months	15.34	20.73	−5.40	−9.84 to −0.94	0.023	46.30
12 months	14.19	16.34	−2.15	−6.69 to 2.28	0.290	5.53
18 months	13.79	15.48	−1.69	−6.22 to 2.84	0.424	4.67
Action and Acceptance Questionnaire
Baseline	38.53	38.53	0.00	−7.87 to 7.87	1.000	0.77
7 months	33.12	36.48	−3.37	−7.95 to 1.21	0.096	30.47
12 months	32.56	37.50	−4.94	−9.44 to −0.45	0.040	121.82
18 months	30.69	36.17	−5.48	−9.44 to −1.52	0.014	55.98
Emotional Approach Coping
Baseline	16.10	16.10	0.00	−3.83 to 3.83	1.000	1.00
7 months	18.38	16.89	1.50	−0.84 to 3.83	0.132	36.36
12 months	18.64	15.10	3.55	1.22 to 5.87	0.017	3242.24
18 months	19.31	16.33	2.98	0.84 to 5.12	0.012	278.72
Modified Scale for Suicide Ideation
Baseline	7.72	7.72	−0.00	−2.92 to 2.92	1.000	0.95
7 months	4.66	6.50	−1.84	−4.49 to 0.80	0.150	17.58
12 months	2.46	3.90	−1.44	−4.03 to 1.15	0.229	5.14
18 months	2.04	1.60	0.45	−2.48 to 3.37	0.753	1.52
Patient Health Questionnaire-9
Baseline	19.24	19.24	−0.00	−5.02 to 5.02	1.000	0.86
7 months	13.24	16.69	−3.45	−6.61 to −0.29	0.041	30.82
12 months	13.04	15.96	−2.92	−6.04 to 0.20	0.058	33.64
18 months	12.87	16.10	−3.23	−6.05 to −0.40	0.030	12.39
Social Support Questionnaire
Baseline	0.15	0.15	0.01	−0.44 to 0.46	0.952	0.92
7 months	0.15	−0.07	0.22	−0.23 to 0.67	0.279	0.15
12 months	0.25	−0.05	0.30	−0.15 to 0.75	0.157	0.10
18 months	0.27	−0.13	0.40	−0.08 to 0.87	0.093	0.20

RO DBT, radically open dialectical behaviour therapy; TAU, treatment as usual; OR, odds ratio.

a. Evidence ratio (d > 0) for hypothesis that RO DBT is better than TAU.