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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Mol Neurobiol. 2020 Apr 7;57(6):2620–2638. doi: 10.1007/s12035-020-01910-9

Fig. 6.

Fig. 6

Early oligodendrocyte precursor cell (OPC) activation and late oligodendrocyte loss in FCG. a The density of OPCs (SOX2 and OLIG2 co-labeled cells) in the retrolaminar ONH of 10–12 week-old cats with early-stage glaucoma was significantly greater than in agematched control ONHs (n = 5 per group). b–d Based on patterns of SOX2 and OLIG2 immunolabeling, density of oligodendrocytes (b), cells of oligodendrocyte-lineage (c), and astrocytes (d) did not significantly differ between early FCG and age-matched normal ONHs. e–h Densities of OPCs (e) and astrocytes (h) were not significantly different in adult cats with chronic FCG compared to age-matched normal cats. In contrast, in the ONH of adult FCG cats, densities of both oligodendrocytes (f) and cells of oligodendrocyte lineage(g) weresignificantly decreased in comparison to normal adult cats (a–d n = 5 for each group, e–h n = 6 for FCG and n = 5 for normal; **P < 0.01; unpaired t test)