Fig 2.

Acute allergic skin inflammation in IL-13–deficient mice recapitulates that in IL-25R–deficient mice. A-E, Representative hematoxylin and eosin staining (A [left]) and epidermal thickness measurement (A [right]), quantitation of percentage of CD4⁺ T cells (B) and mRNA levels of Ccl17 and Ccl22 expressed relative to the mean of WT controls, and (C) heat map of mRNA levels in epidermal sheets (D) and TEWL (E) in ovalbumin (OVA)- and saline (SAL)-sensitized skin of Il13^–/– mice and WT controls Results in A to E are representative of 2 independent experiments with 4 or 5 mice per group. ∗P < .05; ∗∗P < .005. EC, Epicutaneous.