Fig E2.
IL-25 signaling is dispensable for accumulation of basophils and MCs at sites of allergic skin inflammation and for local and systemic TH2 response induced by epicutaneous sensitization. A-D, Percentage of skin basophils and MCs (A), serum ovalbumin (OVA)-specific IgE levels (B), IL-4 and IL-13 secretion by skin-draining lymph nodes (C) and splenocytes (D) and Il25, Tslp, and Il33 mRNA levels in OVA- and saline (SAL)-sensitized Il17rb–/– mice and WT BALB/c controls. Results are representative of 2 independent experiments with 4 or 5 mice per group. Horizontal lines represent means ± SEMs. ∗P < .05; ∗∗P < .005. Calculations performed by using a 2-tailed Student t test.