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. 2020 Jun;145(6):1606–1614.e4. doi: 10.1016/j.jaci.2020.02.026

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© 2020 MRC Laboratory of Molecular Biology. Published by Elsevier Inc. on behalf of the American Academy of Allergy, Asthma & Immunology.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig E3 — Keratinocyte-derived IL-25 is required for acute allergic skin inflammation. A.Il25 mRNA levels in skin from u K14-Cre^Tg/0Il25^flox/flox mice and Il25^flox/flox controls expressed relative to the mean of Il25^flox/flox controls. B-D, Representative hematoxylin and eosin staining (B [left]) and epidermal thickness measurement (B [right]); quantitation of percentage of CD4⁺ T cells (C); and mRNA levels of Il13, Ccl17, and Ccl22 expressed relative to the mean of saline (SAL)-sensitized controls (D) in ovalbumin (OVA)- and SAL-sensitized skin of K14-Cre^Tg/0Il25^flox/flox mice and Il25^flox/flox controls. Results in A to D are representative of 2 independent experiments with 4 or 5 mice per group. ∗P < .05; ∗∗P < .005.