Figure 3.
CXCL14 expression in normal human tissues in different organs (A) and RNA ISH of an HPV-positive tonsil tumor. The graph in (A) was generated in the Genotype-Tissue Expression (GTEx) Portal (gtexportal.org). The data used for the analyses were obtained from the GTEx Portal on 01/22/2020. The images of whole HNC tissue (B) and the magnified areas (C-E) show epithelial cells by cytokeratin immunostaining (red), CXCL14 RNA transcripts by in-situ hybridization (green), and nuclei by DAPI staining (blue). The basal layer of adjacent normal epithelium (C) and the tumor stroma (D and E) exhibit robust CXCL14 expression, while the tumor tissue (D and E) show a lack of CXCL14 expression.