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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Exp Neurol. 2020 Apr 25;330:113321. doi: 10.1016/j.expneurol.2020.113321

Figure 1. Compensated versus uncompensated brain aging as predicted by the mitochondrial cascade hypothesis.

Figure 1.

The sporadic AD mitochondrial cascade hypothesis proposes mitochondrial dysfunction progressively declines with advancing age, which initially prompts compensation (compensated brain aging). At some point, this decline reaches a point at which adequate compensation is no longer possible, and the brain transitions from compensated to uncompensated brain aging. Clinical symptoms and signs are most evident during the stage of uncompensated brain aging.