. Author manuscript; available in PMC: 2021 Jun 1.

Published in final edited form as: J Allergy Clin Immunol. 2020 Jan 28;145(6):1701–1704.e3. doi: 10.1016/j.jaci.2020.01.021

Table E2.

Multivariable Models Assessing Associations Between IL-6 and Risk of Exacerbation and Exacerbation Count Adjusting for other Risk Factors for Exacerbation

	Exacerbation^*		Exacerbation Count

Characteristic	Odds Ratio (95% CI)	P-value	Rate Ratio (95% CI)	P-value
IL-6	1.24 (1.02, 1.51)	0.03	1.21 (1.02, 1.43)	0.03
IL6+Demographics(age, BMI, gender, and race)	1.31 (1.07, 1.61)	0.01	1.24 (1.08, 1.43)	<0.01
IL6+Demographics+WBC+Neutrophil+CRP	1.26 (1.02, 1.55)	0.03	1.20 (1.03, 1.39)	0.02
IL6+Demographics+WBC+Neutrophil+CRP+Total IgE	1.26 (1.02, 1.55)	0.03	1.17 (1.01, 1.35)	0.03
IL6+Demographics+WBC+Neutrophil+CRP+Total IgE+Eosinophil	1.26 (1.02, 1.55)	0.03	1.17 (1.01, 1.35)	0.03
Stepwise model selection	1.31 (1.07, 1.61)	<0.01^†	1.21 (1.02, 1.44)	0.03^‡

The probability of having at least one exacerbation

^†

Age, Total IgE, and IL-6 were used in the model

^‡

Age, Neutrophil, Total IgE, and IL-6 were used in the model