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. Author manuscript; available in PMC: 2021 Jun 1.
Published in final edited form as: Gastroenterology. 2020 Feb 26;158(8):2236–2249.e9. doi: 10.1053/j.gastro.2020.02.034

Figure 2: Localization of apical transporters in the duodenum of neonatal pigs.

Figure 2:

(A) Confocal imaging demonstrated the presence of diffuse SGLT1 below the apical brush border in MYO5B(P663L) enterocytes compared to WT. (B) NHE3 was observed below the apical membrane in MYO5B(P663L) enterocytes with reduced apical localization compared to WT. (C) CFTR was observed on the apical membrane of MYO5B(P663L) enterocytes as in WT. (D) Alkaline phosphatase immunostaining showed intracellular localization of alkaline phosphatase in MYO5B(P663L) pigs compared to WT. Scale bars=50 and 2 μm in low and high magnification respectively.