Table 2. Humphrey visual field (HVF) test parameters of patients with a TBK1 gene duplication at initial and last available examination.
The first available Humphrey visual field (HVF), last available HVF, change in HVF, and rate of change in HVF was recorded in 14 eyes of 7 patients from a single African American pedigree with NTG caused by a TBK1 gene duplication. Rate of change was calculated by compared first and last available HVF tests and by plotting the best linear fit to all of the available HVF data. The rate of change in MD was categorized as “slow” if the rate was less than −0.5 dB/year and “moderate” if the rate was between −0.5 dB/year and −1.0 dB/year. The rate of change in MD was categorized as no change or “NC” if the rate was not statistically different from 0 dB/year. Abbreviations: OD, right eye; OS, left eye; dB, decibels; Mod, moderate; NA, not available due to limited data; NC, no significant change.
| Family Member (Pedigree Symbol) |
II-2 | II-5 | II-9 | III-1 | III-2 | III-6 | III-7 | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HVF Protocol | 24-2 (dB) | 10-2 (dB) | 30-2 or 24-2 (dB) |
10-2 (dB) | 24-2 (dB) | 30-2 or 24-2 (dB) |
10-2 (dB) | 24-2 (dB) | 10-2 (dB) |
24-2 (dB) | 24-2 (dB) | ||||||||||
| Eye | OD | OS | OD | OS | OD | OS | OD | OS | OD | OS | OD | OS | OD | OS | OD | OS | OS | OD | OS | OD | OS |
| First Available HVF | −24.3 | −27.0 | −20.5 | −21.9 | −18.7 | −17.3 | −13.1 | −23.6 | −2.7 | −2.96 | −9.6 | −8.4 | −11.7 | −5.2 | −1.8 | −3.0 | −3.9 | −1.8 | −3.5 | −2.9 | −2.9 |
| Last Available HVF | −25.1 | −28.7 | −28.2 | −27.1 | −23.1 | −28.3 | −23.8 | −32.0 | −3.6 | −3.0 | −29.0 | −27.5 | −25.6 | −15.1 | −2.1 | −8.53 | −4.6 | −1.2 | −2.6 | −2.1 | −2.7 |
| Change in HVF | −0.8 | −1.7 | −7.7 | −5.2 | −4.4 | 11.0 | −10.7 | −8.4 | −0.9 | 0.04 | −19.4 | −19.1 | −13.9 | −9.9 | −0.3 | −5.53 | −0.7 | 0.6 | 0.9 | 0.8 | 0.2 |
| Years of Follow-up | 2 | 2 | 19 | 19 | 15 | 15 | 20 | 20 | 20 | 20 | 24 | 24 | 16 | 16 | 14 | 14 | 2 | 5 | 5 | 15 | 15 |
| Rate of change in HVF (dB/year) | |||||||||||||||||||||
| First and last test only | −0.40 | −0.85 | −0.41 | −0.27 | −0.29 | −0.73 | −0.54 | −0.42 | −0.01 | 0.00 | −0.81 | 0.80 | −0.87 | −0.68 | −0.02 | −0.40 | −0.35 | 0.12 | 0.18 | 0.1 | 0.01 |
| Best linear fit (all data) | NA | NA | −0.30 | −0.22 | −0.44 | −0.77 | −0.57 | −0.48 | 0.00 | −0.03 | −0.80 | 0.84 | −0.74 | −0.52 | −0.23 | −0.51 | NA | −0.04 | 0.06 | 0.02 | −0.04 |
| Rate of Change Category | NA | NA | Slow | Slow | Slow | Mod | Mod | Slow | NC | NC | Mod | Mod | Mod | Mod | Slow | Slow | NA | NA | NA | NC | NC |