Table 2.
Grade 3+ toxicities during radiation therapy and maintenance
| Toxicity | During Radiation (n = 64^) | During Maintenance (n = 52^) | ||
|---|---|---|---|---|
| # of Pts with Grades 3/4/5 Treatment-Related AE | % of Pts with Grades 3/4/5 Treatment-Related AE^ | # of Pts with Grades 3/4/5 Treatment-Related AE | % of Pts with Grades 3/4/5 Treatment-Related AE^ | |
| Lymphocyte count decreased | 21 | 32.8 | 26 | 50.0 |
| Neutrophil count decreased | 3 | 4.7 | 17 | 32.7 |
| White blood cell decreased | 2 | 3.1 | 16 | 30.8 |
| Platelet count decreased | 1 | 1.6 | 12 | 23.1 |
| Anemia | 1 | 1.6 | 2 | 3.8 |
| Hypokalemia | 2 | 3.1 | ||
| Rash maculopapular | 2 | 3.1 | ||
| Hydrocephalus | 1 | 1.6 | ||
| Hypertension | 1 | 1.6 | ||
| Nervous system disorders—other, specify | 1 | 1.6 | ||
| Urinary tract infection | 1 | 1.6 | ||
| Constipation | 1 | 1.6 | ||
| Hypocalcemia | 1 | 1.6 | ||
| Reversible posterior leukoencephalopathy syndrome | 1 | 1.6 | ||
| Seizure | 1 | 1.6 | ||
| Hyponatremia | 1 | 1.9 | ||
| Alanine aminotransferase increased | 1 | 1.9 | ||
| Febrile neutropenia | 1 | 1.9 | ||
| Lung infection | 1 | 1.9 | ||
| Lymphocyte count increased | 1 | 1.9 | ||
Abbreviations: Pts, patients; AE, adverse event.
^ Sixty-four eligible patients received at least some study drug and were considered evaluable for toxicity. The denominator for the RT phase was 64 and the denominator for the maintenance phase was 52 patients who started maintenance.