Table 3.
Pharmacokinetic parameters of veliparib administered concurrently with radiation
| PK Parameters | Units | Veliparib 50 mg/m2 PO b.i.d., n = 6 | Veliparib 65 mg/m2 PO b.i.d., n = 31 | Veliparib 85 mg/m2 PO b.i.d. n = 4 | |||
|---|---|---|---|---|---|---|---|
| Mean | SD | Mean | SD | Mean | SD | ||
| Day 1, Cmax | ng/mL | 519 | 241 | 843 | 290 | 1074 | 372 |
| Day 1, Cmax | μM | 2.12 | 0.98 | 3.45 | 1.19 | 4.40 | 1.52 |
| CL/F | L/m2/h | 16.1 | 8.1 | 12.0 | 8.1 | 15.8 | 8.3 |
| Vd/F | L/m2 | 75.4 | 29.2 | 69.8 | 98.9 | 63.9 | 10.6 |
| Terminal t1/2 | Hr | 5.18 | 6.34 | 2.27 | 2.45 | 4.45 | 4.80 |
| Day 4, Cmax | ng/mL | 409 | 84 | 734 | 284 | 954 | 348 |
| Day 4, Cmax | μM | 1.68 | 0.34 | 3.00 | 1.16 | 3.91 | 1.42 |
| Day 4, trough | ng/mL | 58 | 19 | 95 | 83 | 163 | 97 |
| Day 4, trough | μM | 0.24 | 0.08 | 0.39 | 0.34 | 0.67 | 0.40 |