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Summary of diagnostic performance of urinary biomarkers in differentiating DIPG patients and controls
| Biomarker | Area Under the Curve (95% CI) | Cut-point Based on Youden’s Index | Sensitivity Based on Cut-point | Specificity Based on Cut-point | Accuracy |
|---|---|---|---|---|---|
| Netrin-1 | 0.77 (0.66–0.87) | 0.536 | 98% | 49% | 76% |
| bFGF | 0.75 (0.64–0.86) | 0.419 | 96% | 38% | 70% |
| TIMP-1 | 0.74 (0.63–0.84) | 0.541 | 100% | 8% | 58% |
| MMP-3 | 0.85 (0.76–0.93) | 0.529 | 78% | 81% | 79% |
