Table 2.
Comparison of factors and dosimetric parameters between patients with grade ≤ 1 radiation pneumonitis (RP) and those with grade ≥2 RP.
| Parameter | grade ≤ 1 RP group (n = 23) | grade ≧2 RP group (n = 13) | p-value |
|---|---|---|---|
| Patient factor | |||
| Brinkman Index | 968 (±1085) | 980 (±456) | 0.970 |
| KL-6 | 353 (±175) | 352 (±193) | 0.991 |
| CRP | 0.71 (±1.37) | 1.03 (±1.97) | 0.570 |
| LDH | 176 (±41) | 188 (±39) | 0.401 |
| HbA1c | 6.2 (±0.6) | 6.3 (±0.6) | 0.409 |
| Blood sugar | 116 (±26) | 123 (±36) | 0.491 |
| Age | 70.1 (±7.7) | 72.1 (±5.6) | 0.432 |
| FEV1.0* | 2.22 (±0.41) | 2.20 (±0.53) | 0.946 |
| Dosimetric parameter | |||
| V5, % | 26.8 (±7.7) | 32.2 (±7.1) | 0.044 |
| V10, % | 22.1 (±6.5) | 27.4 (±6.0) | 0.041 |
| V20, % | 17.5 (±5.4) | 22.7 (±5.1) | 0.008 |
| V30, % | 14.2 (±5.1) | 19.3 (±4.6) | 0.006 |
| V40, % | 11.3 (±4.8) | 15.6 (±4.3) | 0.012 |
| V50, % | 8.1 (±4.3) | 11.1 (±3.8) | 0.043 |
| V60, % | 2.2 (±3.0) | 2.7 (±2.1) | 0.627 |
| MLD, Gy | 9.5 (±3.0) | 11.8 (±2.8) | 0.031 |
*Data were taken from 27 patients who underwent respiratory function test. Among 27 patients, 16 patients showed grade ≤1 radiation pneumonitis and 11 patients showed grade ≧2 radiation pneumonitis.
CRP; c-reactive protein, KL-6; sialylated carbohydrate antigen, LDH; lactate dehydrogenase, FEV1.0; forced expiratory volume in one second, MLD; mean lung dose, RP; radiation pneumonitis.