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. 2020 May 18;23(6):101182. doi: 10.1016/j.isci.2020.101182

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© 2020 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Evaluation of Detected Genes in Extracellular Vesicles (EVs) from Pooled or Individual Plasma Samples Using the SMARTer Pico v2 Kit.

Genes were filtered to those with an average of 10 counts across all samples and then normalized using DESeq2.

(A) Box plots showing the total number of genes detected in EV-enriched and no-EV plasma compartments by sample type (pooled versus individual plasma).

(B) Venn diagram showing the number of commonly or uniquely detected genes in no-EV (fractions 1–5) and EV-enriched (fractions 6–10) compartments from pooled plasma samples.

(C) Venn diagram showing the number of commonly or uniquely detected genes in no-EV (fractions 1–5) and EV-enriched (fractions 6–10) compartments from individual plasma samples.