Figure 5.

Modification of adipose tissue inflammation in HFD-fed mice after transplantation of Gipr^−/−BM. Tissue mRNA expression of S100a8, S100a9, cytokines, and chemokines in eWAT (A) and iWAT (B) from 26-week-old WT male mice that received WT (BMT-WT) or Gipr^−/− (BMT-Gipr^−/−) bone marrow at the age of 9 weeks and were fed an RCD (n = 4–7/group) or HFD (n = 4–5/group) for 12 weeks. Data are presented as the mean ± SD. ∗P ≤ 0.05, ∗∗P ≤ 0.01, ∗∗∗P ≤ 0.001, and ∗∗∗∗P ≤ 0.0001. BMT: bone marrow transplant; RCD: regular chow diet; HFD: high-fat diet; eWAT: epididymal white adipose tissue; iWAT: inguinal white adipose tissue.