Table 3.
Linear regression Models for metabolic factors in PD. B(95%CI) and p values are presented for measures found significant in the model.
| Number of metabolic factors | Prediabetes | Hypertension | hypertriglyceridemia | Low HDL | Obesity | |
|---|---|---|---|---|---|---|
| Model | F = 4.928; p < 0.0001 | F = 4.068; p < 0.0001 | F = 2.121; p = 0.026 | F = 3.664; p < 0.0001 | F = 0.838; p = 0.593 | F = 1.299; p = 0.236 |
| Genotype | 0.21(0.03–0.39); 0.02* | 0.095(0.009–0.180); 0.031* | 0.08(0.008–0.165); 0.032^ | |||
| Sex | −0.14(−0.281–0); 0.051 | |||||
| Age | 0.46(0.03–0.06); 0.0001 | 0.022(0.014–0.030); 0.0001 | 0.011(0.003–0.018); 0.004 | 0.018(0.010–0.026); 0.0001 | ||
| Disease duration | −0.82(−0.16–0.002); 0.055 | |||||
| RBDQ | 0.029(0.002–0.057); 0.037 | |||||
| LEDD | ||||||
| UPDRS-III | ||||||
| MOCA | ||||||
| UPSIT | ||||||
| NMSQ |
*- significance driven by iPD; ^- significance driven by LRRK2-PD.
RBDQ- REM sleep Behavior Disorder Questionnaire, LEDD- LevoDopa Equivalent Daily Dose, UPDRS- Unified Parkinson’s Disease Rating Scale part III, MoCA – Montreal Cognitive Assessment, UPSIT- University of Pennsylvania Smell Identification Test, NMSQ- Non-Motor Symptoms questionnaire.