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. 2020 Jun 9;11:2911. doi: 10.1038/s41467-020-16665-z

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2020

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Fig. 6 — Prior to the addition of the agonist, platelet-rich human plasma was incubated for 1 min with either PBS (Crtl) or with the recombinant proteins at the concentrations shown. Aggregometer traces were measured at 37 °C from stirred platelets suspensions on a Chrono-Log platelet aggregometer model 700 for 6 min. An increase of light transmittance over time indicates platelet aggregation. a CxD7L1 and CxD7L2 concentration-dependent inhibition of platelet aggregation induced by low doses of collagen (1 µg/mL). CxD7L1 and CxD7L2 failed to inhibit platelet aggregation induced by b high doses of collagen (10 µg/mL) and c GPVI agonist convulxin (100 pM). Graphs are representative of two measurements. Source data are provided as a Source Data file.