Table 3.
Cox proportional hazards model analysis of factors associated with death (Japanese cohort).
| Characteristics | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| Hazard ratio | 95% CI | P value* | Hazard ratio | 95% CI | P value* | |
| Age | ||||||
| ≤50/>50 | 0.84 | 0.28–2.51 | 0.76 | |||
| Menopausal status | ||||||
| Pre/Post | 0.68 | 0.23–2.0 | 0.49 | |||
| Area of invasive tumour | ||||||
| ≤2 cm/>2 cm | 2.26 | 0.76–6.71 | 0.14 | |||
| Histology | ||||||
| IDC/others | 0.37 | 0.05–2.88 | 0.34 | |||
| Histological grade | ||||||
| 1–2/3 | 10.16 | 2.81–37.1 | 0.0004 | 17.02 | 0.49–589.2 | 0.12 |
| Nuclear grade | ||||||
| 1–2/3 | 7.52 | 2.07–27.34 | 0.002 | 0.5 | 0.01–17.48 | 0.7 |
| Lymphovascular invasion | ||||||
| Negative/Positive | 0.91 | 0.3–2.77 | 0.86 | |||
| Ki67 | ||||||
| <14%/≥14% | 2.74 | 0.84–8.9 | 0.093 | |||
| ACTN4 FISH | ||||||
| NCN/CNI | 5.78 | 1.78–18.77 | 0.0035 | 4.27 | 1.3–14.05 | 0.014 |
IDC intraductal carcinoma, FISH fluorescence in situ hybridisation, NCN normal copy number, CNI copy number increase, CI confidence interval.
*Cox regression analysis. P values of <0.05 are shown in bold.