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. 2020 Jun 9;10:183. doi: 10.1038/s41398-020-0859-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Mouse PBMCs were treated with either individual phenolic acid or the combination of all 4 phenolic acids that found to be significantly higher in the 40mg/kg/day group for 16h and stimulated with LPS for 16h. Cytokine content in the supernatant was measured by multiplex ELISA. a The level of IL-6 (One-way ANOVA, F_7,31 = 15.95, P < 0.0001, n = 4 per culture conditions) and b the level of TNF-α (One-way ANOVA, F_7,31 = 28.46, P < 0.0001, n = 4 per culture conditions). Bar graphs represent mean ± s.e.m., *P < 0.05, **P < 0.01, ***P < 0.001.